By Michael E. Smerconish”For the first time, researchers say they have discovered the molecular mechanism that regulates the risk of male infertility, a potentially life-saving treatment that may be used in countries that lack treatment options for male infertility.
The findings appear online this week in the journal Nature Medicine.””
The study shows that the protein involved in regulating a cell’s ability to make and release sperm can be altered in a mouse model of male fertility, making it potentially valuable for fertility treatments,” said lead author Andrew R. Pash, a postdoctoral researcher in molecular biology at the University of California, Berkeley.
Pash is now at Stanford University in the School of Medicine, where he is also affiliated with the Stanford Human Genome Research Institute.
The research was supported by grants from the National Institutes of Health.
“For many years, it has been known that some genes, particularly in male mice, can control sperm production and release,” said Pash.
“The gene involved in the production of sperm, called MTHFR, is an important component of a complex set of genes known as the ‘male control system,’ which controls how much male hormones can pass into a female’s bloodstream and how quickly it can build up in the body.”
These genes have long been known to play an important role in the male reproductive system and are associated with sperm-making and the likelihood of having children.””
This study shows for the first a possible molecular mechanism of the male control system that is controlled by a protein, called the MTHR protein, that is involved in controlling the expression of this protein in male cells,” said study co-author Stephen E. Stavroff, a professor of molecular biology and biochemistry at the U.S. Department of Energy’s Brookhaven National Laboratory.”
It is the first known direct mapping of this gene to an individual cell in the mouse, and it is the only known example of a protein-directed mutation in a mammalian cell that is functionally and functionally related to male fertility.
“The MTHRI protein, known as an MTH receptor, was first discovered in mice, but the mechanism of its function has remained elusive.”
There is no doubt that the male mouse is a good model for studying the mechanism and molecular biology of male reproduction,” said Stephen P. Stapleton, Ph.”
In this study, we found that the MSTR protein is a major regulator of the MThFR protein, and the MTR gene, which controls the MHC class I and MHC classes II genes, are also important regulators of the cell cycle.”
“There is no doubt that the male mouse is a good model for studying the mechanism and molecular biology of male reproduction,” said Stephen P. Stapleton, Ph.
D., a professor in the UB Department of Genetics and Molecular Biology.
“We can now use these insights to identify molecular pathways that control the function of the human MTH gene, including those involved in normal male fertility.
This opens the door for the next generation of human-specific therapies that target male fertility in people with normal MTH function.”
The findings of the study were published online April 25 in the online journal Nature Communications.